The story begins with the Battletoads visiting the Gyachung-La fortress in northern Tibet. The game was praised for its varied gameplay and music, but criticized for its lack of originality and high difficulty. Battletoads in Battlemaniacs received a mostly positive response from critics, receiving an aggregate score of 78% from GameRankings. Many of its levels are enhanced or remixed versions of levels from the original Battletoads, featuring similar mechanics and gameplay styles. The game follows two Battletoads, Rash and Pimple, on a quest to stop Silas Volkmire and the evil Dark Queen from ruling over the world.

It was released around the same time as Battletoads & Double Dragon, another installment in the series. It was also ported for the Sega Master System and released exclusively in Brazil.

The game was released in North America in June 1993, in Europe in October 1993 and in Japan on January 7, 1994. Battletoads in Battlemaniacs is a 1993 platforming beat 'em up video game developed by Rare and published by Tradewest for the Super Nintendo Entertainment System, part of the Battletoads series.

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